West Brom midfielder Jake Livermore has been called up as a replacement.
Striker Kane has a knee injury while midfielder Winks has an ankle problem. The pair had treatment during the 1-0 win over Crystal Palace on Sunday.
England host Germany at Wembley on Friday and then play Brazil at the same venue on 14 November.
Kane and Winks' Spurs team-mate Dele Alli had already withdrawn from the original squad and on Monday England called up Everton defender Michael Keane to replace him.
Tottenham boss Mauricio Pochettino said Winks, who went off at half-time in the Palace match, had twisted his ankle.
Read More: http://www.bbc.com/sport/football/41893269
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